Information Package / Course Catalogue
Molecular Genetic Data Analysis
Course Code: ZZO511
Course Type: Area Elective
Couse Group: Second Cycle (Master's Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 3
Prt.: 0
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

It is the objective of this course to analyze the databases obtained from molecular genetic applications by using bioinformatics tools and to evaluate the outputs. In addition, it is possible to learn sequence alignment, building a phylogenetic tree, distance calculation between species, evaluation of microarray samples and genomic understanding.

Course Content

Analyzes for data obtained using markers such as RAPD, AFLP, RFLP, Microsatellites, SNP, and Microarray

Name of Lecturer(s)
Assoc. Prof. Onur YILMAZ
Learning Outcomes
1.To apply all knowledge about basic sciences such as mathematics, physics, chemistry and biology to all problems in molecular biology and genetics
2.Be able to obtain knowledge about statistical molecular genetic parameters
3.To prepare of data sets according to different statistical programs
4.To introduce data sets to statistical programs
5.To statistical analyze of molecular genetic data set
Recommended or Required Reading
1.Belkhir, K., Borsa, P., Chikhi, L., Raufaste, N., Bonhomme, F., 2001. GENETIX 4.02, logiciel sous Windows TM pour la génétique des populations. Montpellier: Laboratoire Génome, Populations, Interactions, CNRS. Interactions, CNRS, Université de Montpellier II.
2.Earl, D.A., Vonholdt, B.M., 2012. STRUCTURE HARVESTER: a website and program for visualizing STRUCTURE output and implementing the Evanno method. Conserv Genet Resour 4, 359-361
3.Evanno, G., Regnaut, S., Goudet, J., 2005. Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. MolEcol 14, 2611-2620.
4.Excoffier, L., Lischer, H.E.L., 2010. Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Resour 10, 564-567.
5.Falush, D., Stephens, M., Pritchard, J.K., 2003. Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies. Genetics 164, 1567-1587
Weekly Detailed Course Contents
Week 1 - Theoretical
Definition and types of markers. Definition, types and applications of molecular markers
Week 2 - Theoretical
Definitions of molecular genetic statistical parameters
Week 3 - Theoretical
Data organizing obtained with molecular markers such as sequencing, fragment analysis, RFLP, and SNP
Week 4 - Theoretical
Overview of analysis programs
Week 5 - Theoretical
Data file formats
Week 6 - Theoretical
Use of Bioedit program and interpretation of results
Week 7 - Theoretical
Use of GenAlEx program and interpretation of results
Week 8 - Theoretical
Use of CERVUS program and interpretation of results
Week 9 - Theoretical
Use of Population 1.2.32 program and interpretation of results
Week 10 - Theoretical
Use of Figtree, Genepop and Fstat programs and interpretation of results
Week 11 - Theoretical
Use of Arlequin programs and interpretation of results
Week 12 - Theoretical
Use of Structure, Clumpak and Structure Harvester programs and interpretation of results
Week 13 - Theoretical
Use of Genome studio program and interpretation of results
Week 14 - Theoretical
Use of Plink program and interpretation of results
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%30
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory143384
Assignment98181
Midterm Examination114115
Final Examination114115
TOTAL WORKLOAD (hours)195
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
OÇ-1
5
5
5
5
4
4
4
OÇ-2
5
5
OÇ-3
4
5
4
OÇ-4
4
5
4
5
5
OÇ-5
5
5
5
5
Adnan Menderes University - Information Package / Course Catalogue
2026