Information Package / Course Catalogue
Signaling and Signaling Pathways of Stem Cell
Course Code: KHÜ523
Course Type: Area Elective
Couse Group: Second Cycle (Master's Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 3
Prt.: 0
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

To teach the concepts related to signal transduction and mechanism in stem cell biology and to explain their reflection potential to the clinic.

Course Content

Understanding of signal transduction, ligands, receptors and concepts in stem cell molecular biology. Stem cell division and signaling changes in life, stem cell-related signaling pathways and the role of transcriptional regulators are the understanding of stem cell markers.

Name of Lecturer(s)
Prof. İrfan YAVAŞOĞLU
Learning Outcomes
1.Gains in-depth knowledge about signal transduction in stem cells.
2.Discusses stem cell-specific signaling pathways and transcription factors.
3.Knows how to transmit signal to stem cells
4.Have knowledge about surface membrane communication and polarity in stem cells
5.Know the markers of germ layers in stem cells
Recommended or Required Reading
1.Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
2.The Biology of Cancer. Robert A. Weinberg, Gariand Science 2007
Weekly Detailed Course Contents
Week 1 - Theoretical
Stem cell signaling overview
Week 2 - Theoretical
Ligands and receptors in stem cell signal transduction
Week 3 - Theoretical
Stem cell division and symmetry
Week 4 - Theoretical
Transmission of the signal to the stem cell (kinases, phosphatases, phospholipases, nucleotide cyclases)
Week 5 - Theoretical
Stem cell and transcription factors
Week 6 - Theoretical
Surface membrane communication and polarity in stem cells
Week 7 - Theoretical
Markers of germ layers in stem cells
Week 8 - Intermediate Exam
Mid-term exam
Week 9 - Theoretical
Stem cell and Wnt pathway
Week 10 - Theoretical
Stem cell and Notch pathway
Week 11 - Theoretical
Stem cell and YAP / TAZ pathway
Week 12 - Theoretical
Stem cell and Hedgehog pathway
Week 13 - Theoretical
Stem cell and TGF-beta pathway
Week 14 - Theoretical
Stem cell and BMP pathway
Week 15 - Final Exam
Final exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%20
Final Examination1%60
Assignment1%20
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory131352
Assignment415268
Midterm Examination124226
Final Examination148250
TOTAL WORKLOAD (hours)196
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
OÇ-1
3
2
3
3
1
2
OÇ-2
4
2
3
4
2
2
OÇ-3
4
2
3
4
2
2
OÇ-4
4
2
3
4
2
2
OÇ-5
4
2
3
4
2
2
Adnan Menderes University - Information Package / Course Catalogue