1. The purpose of this course is to make students knowledgeable about basic and essential concepts of nucleic acids and proteins which are the 4 of macromolecules of living organisms at advanced level 2. Additionally, the graduate students of the course gain knowledge about physical, structural, functional properties of these biomolecules and also understand how these properties are related to each other.

Physical properties of nucleic acids, isolation methods, principles of DNA reassociation and RNA hybridization experiments, genome complexities, recombinant DNA procedures and nucleotide sequence analysis, DNAs and RNAs as catalysists. Interaction of nucleic acids with proteins such as repressors, restriction and modification enzymes, RNA recognition. The relationship between protein structure and function. Topics include binding specificity, cooperativity and allostery, protein folding, evolution and macromolecular assembly, sequence homology and prediction of structure.