Information Package / Course Catalogue
Basic Principles in Toxicology - II (Toxicokinetics, Relationship Between Their Dose and Effect)
Course Code: VFT626
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 0
Credit: 2
Lab: 0
ECTS: 6
Objectives of the Course

To give information about toxicokinetics in toxicology and related access roads to the body of poisons, the absorption, distribution-accumulation, biotransformation, disposal, and the importance of the kinetic values.

Course Content

Toxicokinetics in toxicology and related access roads to the body of poisons, the absorption, distribution-accumulation, biotransformation, disposal, and the importance of the kinetic values are examined.

Name of Lecturer(s)
Prof. Ferda AKAR
Learning Outcomes
1.To obtain information on toxicokinetics.
2.To obtain information on dose-effect relationship poisons density.
3.To learn knowledge and propose suggestions on the area.
4.To find out and use resources about the profession in the area.
5.To give lectures and/or presentations and discuss with professionals in the area.
Recommended or Required Reading
1.1. Principles and Methods of Toxicology, A. Wallace HAYES, Edward BROTHERS; Ann Arbor Press, 2001.
2.2. Modern Toxicology, Ernest HODGSON, Patricia E. LEVI; Elsevier, London, 1987.
3.3. Handbook of Experimental Pharmacology – 199; Comparative and Veterinary Pharmacology, Fiona CUNNINGHAM, Jonathan ELLIOTT, Peter LEES (Editors); Springer Press, 2009.
4.4. Plant Phenolics and Human Health: Biochemistry, Nutrition, Pharmacology, Cesar G FRAGA (Editor); A John Willey & Sons Inc. Publication, 2010.
5.5. Principles of Biochemical Toxicology, 3rd Edition, John TIMBRELL; Taylor & Francis Group Press, London, 2000.
Weekly Detailed Course Contents
Week 1 - Theoretical
Poison-drug-related physiological substance
Week 2 - Theoretical
Toxicokinetics
Week 3 - Theoretical
Absorption and transport of poisons
Week 4 - Theoretical
The distribution of toxins in the organism
Week 5 - Theoretical
Biotransformation of toxins
Week 6 - Theoretical
Disposal of poisons
Week 7 - Theoretical
Disposal of poisons
Week 8 - Theoretical
(Midterm exam) Dose-density relation
Week 9 - Theoretical
Repeated exposure to doses of
Week 10 - Theoretical
Dose-effect relationship
Week 11 - Theoretical
Acute poisonings
Week 12 - Theoretical
Subacute poisoning
Week 13 - Theoretical
Chronic poisoning
Week 14 - Theoretical
Article review and discussion
Week 15 - Final Exam
Final exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%30
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory144284
Assignment55235
Midterm Examination112214
Final Examination112214
TOTAL WORKLOAD (hours)147
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
PÇ-13
PÇ-14
PÇ-15
PÇ-16
OÇ-1
4
5
3
4
5
4
OÇ-2
4
5
3
4
5
4
OÇ-3
4
5
4
4
OÇ-4
4
5
4
OÇ-5
4
5
5
Adnan Menderes University - Information Package / Course Catalogue
2026