To introduce the topics in probability and statistics useful in computational molecular biology and bioinformatics.

Brief history of Bioinformatics, Basic concepts of Molecular Biology, Markov Chain, The Analysis of one DNA sequence, Modeling DNA and signals in DNA, Alignments and simple tests for significant similarity in an Alignment(BLAST technique), Alignment algorithms for two sequences and dynamic programming, Entropy and related concepts, Relative entropy and binding energy, Finding instances of known and unknown Sites, Correlation of positions in sequences, Gene expression, microarrays, and multiple testing, Evolutionary models/ Phylogenetic tree estimation.