Information Package / Course Catalogue
Nutrigenomics and Nutrigenetics: Genetic Foundations of Nutrition
Course Code: BİO655
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 3
Prt.: 0
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

This course aims to explain how genetic variations influence biological responses to dietary components and to provide advanced knowledge on the interactions between nutrition, genomics, and epigenetics. Students are expected to develop the ability to scientifically evaluate personalized nutrition approaches based on individual genetic profiles, interpret nutrigenetic and nutrigenomic data, analyze gene–diet interactions at the molecular level, and apply this knowledge to health promotion and disease management. Additionally, the course aims to foster a multidisciplinary perspective by addressing the ethical, societal, and clinical implications of nutrigenomic data.

Course Content

This course focuses on nutrigenetics and nutrigenomics, which examine how individuals’ genetic makeup influences their responses to dietary components and the effects of nutrition on gene expression. It covers nutrition–genome interactions at the levels of the genome, epigenome, transcriptome, and metabolome, as well as the scientific basis of personalized nutrition strategies and their applications in public health. The course also discusses the impact of gene–diet interactions on chronic diseases such as obesity, diabetes, cardiovascular diseases, and cancer. Students will gain advanced knowledge and analytical skills related to nutrition-sensitive genetic variations, analysis of nutrigenetic biomarkers, epigenetic mechanisms, and individualized medical nutrition approaches.

Name of Lecturer(s)
Assoc. Prof. Tülay ÇELİK
Learning Outcomes
1.Defines the concepts of nutrigenomics and nutrigenetics, and explains the differences between them.
2.Analyzes the effects of nutrients on gene expression and epigenetic mechanisms.
3.Evaluates the relationship between genetic polymorphisms and individual dietary responses.
4.Interprets gene-diet interactions in common diseases such as obesity, diabetes, cardiovascular diseases, and cancer.
5.Discusses the applicability and limitations of nutrigenetic testing from a scientific perspective.
6.Explains the tripartite relationship between microbiota, genetic makeup, and nutrition.
7.Assesses the scientific basis and potential health impacts of personalized nutrition approaches.
8.Analyzes the ethical, social, and legal aspects of nutrigenomic applications.
Recommended or Required Reading
1.Carlberg C, Ulven AM, Molnar F. 2019. Nutrigenomik. Çeviri Editörleri: Yılmaz, S., Uçar A. Pelikan Kitabevi. ISBN: 9786052268919
2.Bş, M., Karaca E. 2023. Nutrigenetik Kişisel Beslenme Bilimini Uygulamak. Akademisyen Yayınevi
3.Temizkan, G. 2021. Genetik: Temel İlke ve Kavramlar. Ankara Nobel Tıp Kitabevi. ISBN: 9786257564045. -
4.Ordovas JM. 2004. Nutrigenetics And Nutrigenomics, World Review of Nutrition and Dietetics,Vol.93,Karger, 2004
Weekly Detailed Course Contents
Week 1 - Theoretical
Introduction to Nutrigenomics and Nutrigenetics: Definitions, Historical Development, and Importance
Week 2 - Theoretical
Genetic Diversity and Individual Nutritional Differences
Week 3 - Theoretical
Gene-Diet Interaction: Regulation of Gene Expression by Nutrients
Week 4 - Theoretical
Epigenetic Mechanisms and Nutrition: DNA Methylation, Histone Modifications
Week 5 - Theoretical
Genetic Variations and Polymorphisms: Individual Differences in Nutrient Response
Week 6 - Theoretical
Nutrigenetics-Based Personalized Nutrition Approaches
Week 7 - Theoretical
Gene-Diet Interactions in Obesity and Metabolic Diseases
Week 8 - Theoretical
Literature Presentations (Midterm Exam)
Week 9 - Theoretical
Cancer and Diet: Genetic Predisposition and Protective/Harmful Effects of Nutrients
Week 10 - Theoretical
Cancer and Nutrigenomics: Role of Nutrition in Oncogenesis and Protective Strategies
Week 11 - Theoretical
Relationships Between Microbiota, Genetic Makeup, and Nutrition
Week 12 - Theoretical
Nutrigenetic Testing and Personalized Nutrition Approaches
Week 13 - Theoretical
Advanced Technologies in Nutrigenomics: Genomic, Transcriptomic, and Metabolomic Analyses
Week 14 - Theoretical
Ethical, Social, and Legal Aspects of Nutrigenetic Testing
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%30
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory142370
Assignment210224
Reading123036
Individual Work104040
Midterm Examination110212
Final Examination120222
TOTAL WORKLOAD (hours)204
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
PÇ-13
PÇ-14
OÇ-1
5
4
3
2
4
3
3
4
4
3
OÇ-2
4
5
4
3
4
3
3
4
3
4
OÇ-3
5
5
4
2
4
3
3
4
4
3
OÇ-4
5
5
4
3
4
4
3
5
5
4
OÇ-5
4
5
4
2
4
4
3
4
4
3
OÇ-6
4
3
3
3
3
3
2
2
4
4
OÇ-7
3
3
3
2
3
2
2
3
3
2
OÇ-8
3
3
3
2
3
3
3
4
4
2
Adnan Menderes University - Information Package / Course Catalogue
2026