Information Package / Course Catalogue
Oligonucleotide Technology in Clinic Diagnosis and Treatment
Course Code: MBTK646
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: English
Work Placement: N/A
Theory: 3
Prt.: 0
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

The aim of this course is to give ability to providing knowledge and skills on the use of oligonucleotides in diagnosis and treatment

Course Content

Applications on the structure, formulations, targeting of oligonucleotides, their use in clinical applications and their productive stages will be explained.

Name of Lecturer(s)
Prof. Özge ÇEVİK
Learning Outcomes
1.To have knowledge about nucleic acids
2.To have knowledge about oligonucleotides and their synthesis
3.To be able to design oligonucleotides
4.To comprehend how oligonucleotides can be used therapeutically in clinic
5.To understand the usage areas of oligonucleotides in diagnosis and to have knowledge about the development of new products
Recommended or Required Reading
1.All scientific journals and textbook on recombinant proteins
Weekly Detailed Course Contents
Week 1 - Theoretical
Structure of nucleic acids
Week 2 - Theoretical
Synthesis of nucleic acids
Week 3 - Theoretical
Destruction of nucleic acids
Week 4 - Theoretical
Modifications of nucleic acids
Week 5 - Theoretical
Binding reactions of nucleic acids with biomolecules
Week 6 - Theoretical
Structure and synthetic modifications of oligonucleotides
Week 7 - Theoretical
Types of oligonucleotides-I (Aptamers, ASO, Probes, Primers, libraries, other DNA and RNA types etc.)
Week 8 - Theoretical
Types of oligonucleotides-II (Aptamers, ASO, Probes, Primers, libraries, other DNA and RNA types etc.) (Midterm exam)
Week 9 - Theoretical
Usage areas of oligonucleotides in treatment
Week 10 - Theoretical
Oligonucleotide-based drugs
Week 11 - Theoretical
The use of oligonucleotides in controlled drug release
Week 12 - Theoretical
Usage areas of oligonucleotides in diagnosis
Week 13 - Theoretical
Examples of use of oligonucleotides in diagnostic kits
Week 14 - Theoretical
Oligonucleotide design methods, sample application
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%30
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory140342
Assignment401560
Term Project20510
Laboratory20510
Reading130565
Quiz20510
Midterm Examination1033
Final Examination1033
TOTAL WORKLOAD (hours)203
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
PÇ-13
OÇ-1
4
4
3
OÇ-2
3
4
4
OÇ-3
4
4
3
OÇ-4
3
4
5
OÇ-5
4
4
3
4
Adnan Menderes University - Information Package / Course Catalogue
2026