Information Package / Course Catalogue
Genotoxicology and Molecular Testing Methods
Course Code: TG017
Course Type: Non Departmental Elective
Couse Group: Short Cycle (Associate's Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 0
Credit: 2
Lab: 0
ECTS: 2
Objectives of the Course

The aim of this course is to familiarize healthcare professionals with the importance of Genotoxicology, the difference between mutation and genotoxicity, genotoxic agents and DNA damage concepts, and to learn Molecular Testing Methods.

Course Content

Genetic toxicology is a subdiscipline of toxicology that deals with the potential for damage to genetic material, deoxyribonucleic acid (DNA), by various endogenous or exogenous mechanisms. DNA damage can range from gene mutations to major chromosomal changes. Such DNA damage is implicated in many human diseases and disorders, including hereditary effects and malignancy (cancer), a multistage process. It is vital to screen for compounds with potential genotoxic activity that are likely to be human exposures in order to control, eliminate, and prevent unwarranted exposure to such compounds. In this course, the student learns to perform toxicant analysis using genetic testing techniques.

Name of Lecturer(s)
Lec. Halit KIZILET
Learning Outcomes
1.To recognize genotoxicology and genotoxic agents.
2.To learn DNA damage concepts.
3.Learning the difference between mutation and genotoxicity
4.Evaluation of Genotoxic Test Methods in OECD Standards
5.Learning diagnosis and treatment with a multidisciplinary approach
Recommended or Required Reading
1.Principles of Genetic Toxicology (T. M. Krishna Murthy)
2.Molecular Toxicology (P. W. Sturrock)
3.OECD Testing Guide
Weekly Detailed Course Contents
Week 1 - Theoretical
What is genotoxicity? The place and importance of genotoxicology in toxicology
Week 2 - Theoretical
DNA Damage Mechanisms
Week 3 - Theoretical
DNA Repair Systems
Week 4 - Theoretical
Genotoxicity Test Methods: In vitro
Week 5 - Theoretical
Genotoxicity Test Methods: In vivo
Week 6 - Theoretical
Molecular Testing Methods
Week 7 - Theoretical
Molecular Testing Methods
Week 8 - Theoretical
New Generation Genotoxicity Tests / Midterm Exam
Week 9 - Theoretical
Regulation and Standards
Week 10 - Theoretical
Genotoxicity Assessment and Risk Analysis
Week 11 - Theoretical
Case Studies
Week 12 - Theoretical
Drug development processes
Week 13 - Theoretical
Genotoxicity in food safety and environmental toxicology
Week 14 - Theoretical
Examples of industrial and occupational exposure
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%40
Final Examination1%60
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory140228
Assignment52115
Midterm Examination1213
Final Examination1314
TOTAL WORKLOAD (hours)50
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
OÇ-1
3
2
4
3
3
5
2
4
3
3
OÇ-2
3
2
5
3
3
5
2
4
3
3
OÇ-3
3
2
4
3
3
5
2
4
3
3
OÇ-4
3
3
5
4
4
4
2
5
3
4
OÇ-5
3
3
4
3
4
4
4
5
3
4
Adnan Menderes University - Information Package / Course Catalogue
2026