Information Package / Course Catalogue
Biochemistry I
Course Code: KMY351
Course Type: Required
Couse Group: First Cycle (Bachelor's Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 4
Prt.: 0
Credit: 4
Lab: 0
ECTS: 6
Objectives of the Course

This course is designed for fourth year students and includes the basic topics of biochemistry. The chemical structures and functions of biological compounds are examined within the scope of this course. The course also covers basic concepts in preparation for Biochemistry II.

Course Content

Recognition of biomolecules, learning their chemical structures. Learning basic biochemistry concepts.

Name of Lecturer(s)
Prof. Murat UYGUN
Learning Outcomes
1.Understands cell types and their contents.
2.Recognizes basic amino acids and learns their chemical properties.
3.Learns the chemical structures of proteins, their importance in living systems, three-dimensional structures of proteins and protein analysis.
4.Understands the enzyme concept and enzymology terms, the names of certain enzymes and the chemical basis of activity assays.
5.Learns the importance of carbohydrates, their chemical composition and properties, and the chemical basis of analysis of carbohydrates.
6.Obtains information about lipids, their components, chemical properties and functions.
7.Gains information about the chemical components of DNA and RNA molecules, their three-dimensional structure and functions, their functioning, control, genes and genetics.
Recommended or Required Reading
1.Biyokimya Cilt I Prof. Dr. Engin M. Gözükara Nobel Kitabevi, 2011. Lecture Notes (Prof. Dr. A: Alev karagözler; Yrd. Doç. Dr. Deniz Aktaş Uygun).
2.Lehninger Principles of Biochemistry. Prof. Dr. Y. Murat ELÇİN (Ed.) Palme Yayıncılık, 2013
3.Biochemistry I Lecture Notes (Prof. Dr. A. Alev Karagözler; Prof. Dr. Deniz Aktaş Uygun).
Weekly Detailed Course Contents
Week 1 - Theoretical
Introduction to Biochemistry. History. Definition and milestones of Biochemistry. General approach to biomolecules.
Week 2 - Theoretical
The cell. Types of cells. Prokaryotic and eukaryotic cells. Names and functions of cell organelles.
Week 3 - Theoretical
Amino acids. Definition. Formula and three and single letter notation of essential and non-essential amino acids. Chemical reactions and analysis of amino acids.
Week 4 - Theoretical
Proteins. Definition and history. Peptide bond. Classification of proteins according to their functions. Primary, secondary, tertiary and quaternary structure of proteins. Classification of proteins according to their three-dimensional structure. Collagen, keratin, elastin, myoglobin, hemoglobin. Classification of proteins according to the complex formed with other molecules.
Week 5 - Theoretical
Purification and analysis of proteins. Analysis of amino acid sequences of proteins: Sanger, Edman. Denaturation and renaturation of proteins.
Week 6 - Theoretical
Introduction to enzymes. Definition and history. Basic terms used in enzymology. General properties of enzymes. Enzyme active site. Theories on enzyme active site. Enzyme activity and activity units. Introduction to enzymes. Description and history. Basic terms used in enzymology. General properties of enzymes. Features that distinguish enzymes from other catalysts. Enzyme active center and theories regarding active center-substrate relationship. Enzyme activity, activity units.
Week 7 - Theoretical
Factors affecting enzyme activity: effect of pH, temperature, enzyme concentration, substrate concentration. Michaelis-Menten equation and usage of this equation. Lineweaver-Burk equation. Enzyme inhibition and types of inhibition. Allosteric enzymes. Isoenzymes. Nomenclature and classification of enzymes. Importance and use of enzymes in medicine and industry.
Week 8 - Theoretical
Carbohydrates. Definition and significance. Glycosidic bond. Classification of carbohydrates according to number of carbon atoms, number of simple sugars, and aldehyde and ketone groups. (Midterm Examination)
Week 9 - Theoretical
Molecular structure properties of sugars. Stereoisomerism, mutorotation conformational isomerism. Chemical properties of sugars: Osazone formation, formation of sugar alcohols, formation of sugar acids, reducing properties of sugars. Polysaccharide compounds found in animal tissues.
Week 10 - Theoretical
Lipids. Definition, significance and function. Chemical structure and properties of fatty acids. Classification of lipids according to chemical structure.
Week 11 - Theoretical
Complex and simple lipids. Micelle and bilayer formation of lipids. Structure of cell membrane.
Week 12 - Theoretical
Structure and function of nucleic acids. History. Experiments evidencing that DNA is the genetic material. Chemical structure of nucleic acids: DNA and RNA. Watson and Crick’s DNA double helix structure. Structure and function differences between DNA and RNA molecules. Types of RNA.
Week 13 - Theoretical
Chemical properties of DNA molecule: Acidity, viscosity, sedimantetion, denaturation and renaturation, hibridization.
Week 14 - Theoretical
Similarities and differences between prokaryotic and eukaryotic cell DNAs. Methods for determining the base sequence of the DNA molecule: Maxam-Gilbert and Sanger-Coulson methods.
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%20
Final Examination1%60
Quiz2%20
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory140456
Reading221022
Quiz2216
Midterm Examination125227
Final Examination140242
TOTAL WORKLOAD (hours)153
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
OÇ-1
5
5
5
OÇ-2
3
3
3
OÇ-3
5
5
5
OÇ-4
5
5
OÇ-5
4
4
5
5
5
OÇ-6
4
4
OÇ-7
5
5
5
5
5
Adnan Menderes University - Information Package / Course Catalogue
2026