Information Package / Course Catalogue
Cancer Stem Cell
Course Code: ONK528
Course Type: Area Elective
Couse Group: Second Cycle (Master's Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 0
Credit: 2
Lab: 0
ECTS: 6
Objectives of the Course

To comprehend the biological, molecular and genetic characteristics of cancer stem cells as translational correlations with clinical parameters.

Course Content

To give information about cancer stem cell concept in cancer biology and its reflection to clinic. For this purpose, the definition and history of stem cells, self-renewal and differentiation, characteristics of cancer stem cells, the function of stem cells in cancer formation, cancer stem cell-related signaling pathways, the importance of stem cells in hematopoietic cancers, the importance of stem cells in solid tumors, tissue-specific stem cell markers, The role of cancer stem cells in resistance to treatment, Cancer Stem Cell, Cancer Stem cell isolation and identification techniques as treatment targets will be explained. Review articles will be discussed.

Name of Lecturer(s)
Learning Outcomes
1.To have in-depth knowledge of cancer stem cells
2.Explain cancer stem cell production and identification
3.Discuss the relationship between cancer stem cells in treatment resistance
4.Knows the role of cancer stem cells in cancer metastasis and recurrence
5.Distinguish specific signaling pathways to cancer stem cells
Recommended or Required Reading
1.Cancer Stem Cells, Vinagolu K. Rajasekhar, Wiley-Blackwell, 2014, ISBN 9781118356203
Weekly Detailed Course Contents
Week 1 - Theoretical
Stem cell or cancer initiator cell?
Week 2 - Theoretical
Definition and Morphology of Stem Cells
Week 3 - Theoretical
Self-renewal and differentiation
Week 4 - Theoretical
Characteristics of Cancer Stem Cells
Week 5 - Theoretical
Cancer stem cell characterization
Week 6 - Theoretical
Cancer Stem Cell Isolation Techniques
Week 7 - Theoretical
Stem cell function in cancer formation-1
Week 8 - Theoretical
Stem cell function in cancer formation-2 (Mid-term exam)
Week 9 - Theoretical
Cancer Stem Cell Related Signal Pathways-I
Week 10 - Theoretical
Cancer Stem Cell Related Signal Pathways-II
Week 11 - Theoretical
Tissue Specific Stem Cell Markers
Week 12 - Theoretical
Importance of Stem Cells in Hematopoietic Cancers
Week 13 - Theoretical
Importance of Stem Cells in Solid Tumors
Week 14 - Theoretical
The Role of Cancer Stem Cells in Treatment Resistance
Week 15 - Final Exam
Final exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Assignment1%5
Quiz1%5
Midterm Examination1%20
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory141242
Assignment118119
Quiz112113
Midterm Examination124226
Final Examination148250
TOTAL WORKLOAD (hours)150
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
PÇ-13
PÇ-14
OÇ-1
4
3
4
3
3
4
3
4
2
3
OÇ-2
4
3
4
4
3
4
3
4
2
3
OÇ-3
4
3
4
3
3
4
3
4
2
3
OÇ-4
4
3
4
3
3
4
3
4
2
3
OÇ-5
4
3
4
3
3
4
3
4
2
3
Adnan Menderes University - Information Package / Course Catalogue
2026