Information Package / Course Catalogue - Adnan Menderes University

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Calculation of Pharmacokinetics Parameters

Course Code	: VFT554
Course Type	: Area Elective
Couse Group	: Second Cycle (Master's Degree)
Education Language	: Turkish
Work Placement	: N/A

Theory	: 1
Prt.	: 2
Credit	: 2
Lab	: 0
ECTS	: 4

Objectives of the Course

Pharmacokinetics moddeleme, kinetic parameters and factors affecting them with the WinNonlin software program utilized in the calculation of these parameters provide information about.

Course Content

Behavior of drugs in the body (absorption, distribution, metabolism, and excretion), pharmacokinetic modeling, pharmacokinetic parameters (AUC, Tmax, T1 / 2, OKS, Cl, Vd), the factors that lead to changes in these parameters (age, species, race, disease, genetic , the environment, etc.). drug efficacy and the effects of measures to be taken in this case and the WinNonlin pharmacokinetic software package

Name of Lecturer(s)

Learning Outcomes

1.	Definition and importance of pharmacokinetics
2.	Pharmacokinetic study planning
3.	pharmacokinetic modeling
4.	Pharmacokinetic parameters and factors affecting them
5.	Calculation of pharmacokinetic parameters

Recommended or Required Reading

1.	Veterinary Pharmacology and Therapeutics, 8th Edition, Jim E. Riviere (Editor), Mark G. Papich (Editor), 2009.
2.	Modern Pharmacology, 6th Edition, Lippincott Williams and Wilkins, 2004 (Ed. C.R. Craig and R.E. Stitzel)
3.	Basic and Clinical Pharmacology, 9th Edition, McGraw-Hill, New York, 2004 (Ed. B. Katzung)
4.	Goodman and Gilman’s The Pharmacological Basis of Therapeutics 11th Edition, McGraw-Hill, 2006 (Eds. Brunton, Lazo, Parker, Buxton and Blumenthal)
5.	Lippincott's Illustrated Reviews: Pharmacology, 3rd Edition, Lippincott Williams and Wilkins, 2005 (Eds. Howard, Mycek, Harvey & Champe)
6.	The Veterinary Formulary edited by Yolande Bishop. London Pharmaceutical Press in association with the British Veterinary Association 2001.
7.	Pharmacology. Franklin A. Ahrens. Baltimore, Md. London Williams & Wilkins 1996.
8.	The physiological basis of veterinary clinical pharmacology J. Desmond Baggot. Oxford Blackwell Science 2001.
9.	Veterinary pharmaclgy and therapeutics edited by H. Richard Adams. Ames, Iwa Iwa State University Press 2001.

Weekly Detailed Course Contents

Week 1 - Theoretical

Definition and importance of pharmacokinetics

Week 1 - Practice

Pharmacokinetic study planning

Week 2 - Theoretical

Factors affecting the pharmacokinetics of

Week 2 - Practice

Pharmacokinetic studies materials required

Week 3 - Theoretical

Pharmacokinetic study plan

Week 3 - Practice

Sample collection and storage

Week 4 - Theoretical

Pharmacokinetic studies points to be considered

Week 4 - Practice

pharmacokinetic studies

Week 5 - Theoretical

pharmacokinetic parameters

Week 5 - Practice

Chromatographic analysis of pharmacokinetic studies

Week 6 - Theoretical

After application of intravenous drug FK

Week 6 - Practice

Creating plasma concentration-time curve

Week 7 - Theoretical

Other routes of drug administration and post-FK

Week 7 - Practice