Information Package / Course Catalogue
| Course Code | : MBTK541 |
| Course Type | : Area Elective |
| Couse Group | : Second Cycle (Master's Degree) |
| Education Language | : Turkish |
| Work Placement | : N/A |
| Theory | : 3 |
| Prt. | : 0 |
| Credit | : 3 |
| Lab | : 0 |
| ECTS | : 8 |
The aim of the course is to teach the epigenetic mechanisms and their relation to gene expression regulation. In particular, the role of epigenetic controls in normal development and cell differentiation will be emphasized. It will also show how epigenetic disorders lead to human pathologies.
Brief Description: Topics that cover the functions of epigenetic mechanisms in gene regulation in mammals will be studied extensively. As content; DNA methylation, histone modifications, chromatin modeling, genomic imprinting, X-inactivation, role of epigenetics in cancer formation and miRNAs, epigenetic laboratory and computational analyzes, epigenetic reprogramming of stem cells and epigenetic controls have functions in development and immunocyte. It will also focus on the role of epigenetic control deficits in the emergence of diseases.
| 1. | Basic mechanisms of epigenetics, gene regulation |
| 2. | Epigenetic anomalies |
| 3. | Role of epigenetics in cancer |
| 4. | Epigenetic research methods |
| 5. | Epigenetics of complex diseases |
| 1. | 1. Epigenetics, C. David Allis, Thomas Jenuwein, Danny Reinberg, Marie-Laure Caparros. Cold Spring Harbour Laboratory Press, New York, 2007 |
| 2. | 2. Epigenetics and Chromatin (Progress in MolecularAndSubcellularBiology).PhilippeJeanteur (Editor), SpringerPress, New York, 2008 |
| 3. | 3. Peter A. Jones & Stephen B. Baylin. The Fundamental Role of Epigenetic Events in Cancer.Nature Reviews Genetics 3, 415-428 (June 2002). |
| 4. | 4. DNA Methylation Patterns and Epigenetic Memory. Genes & Dev. 2002. 16: 6-21 |
| Type of Assessment | Count | Percent |
|---|---|---|
| Assignment | 1 | %5 |
| Quiz | 2 | %5 |
| Midterm Examination | 1 | %20 |
| Final Examination | 1 | %70 |
| Activities | Count | Preparation | Time | Total Work Load (hours) |
|---|---|---|---|---|
| Lecture - Theory | 14 | 7 | 3 | 140 |
| Assignment | 1 | 20 | 1 | 21 |
| Quiz | 2 | 4 | 0 | 8 |
| Midterm Examination | 1 | 14 | 1 | 15 |
| Final Examination | 1 | 14 | 1 | 15 |
| TOTAL WORKLOAD (hours) | 199 | |||
PÇ-1 | PÇ-2 | PÇ-3 | PÇ-4 | PÇ-5 | PÇ-6 | PÇ-7 | PÇ-8 | PÇ-9 | PÇ-10 | PÇ-11 | PÇ-12 | PÇ-13 | |
OÇ-1 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
OÇ-2 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
OÇ-3 | 5 | 5 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
OÇ-4 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
OÇ-5 | 5 | 5 | 4 | 5 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |