Information Package / Course Catalogue - Adnan Menderes University

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Dsrna Genetic Elements

Course Code	: ZBK623
Course Type	: Area Elective
Couse Group	: Third Cycle (Doctorate Degree)
Education Language	: Turkish
Work Placement	: N/A

Theory	: 3
Prt.	: 0
Credit	: 3
Lab	: 0
ECTS	: 6

Objectives of the Course

Current knowledge of dsRNA genetic factors from different biological systems are unified on this course.

Course Content

The course has cover that the nature, origin and biological roles of double-stranded RNA that are capable of replication in fungi, plants and animals. It has convey that dsRNA biology could allow us to create solutions for problems ranging from plant disease management. dsRNA are powerful means of modulating gene expression. Presence of small amounts of dsRNA elicits sequence-specific gene silencing, which may lead to the development of treatments aimed at silencing harmful genes causing serious diseases in animals and humans.

Name of Lecturer(s)

Learning Outcomes

1.	Understanding of dsRNA genetic elements…
2.	The use of dsRNA genetic elements in the prevention of plant diseases
3.
4.
5.

Recommended or Required Reading

1.	Tavantzis S.M. 2002. dsRNA Genetic Elements. CRC Pres, 304 pp
2.	Buck, K.W.1986. Fungal Virology- an overview. CRC Pres. Boca Raton, FL:pp. 1-84
3.	Ghabrial, S.A. 1998. Origin, adaptation and evolutionary pathways of fungal viruses. Virus Genes 16,119-131.
4.	Ghabrial, S.A. and Hillman, B.I. 1999. dsRNA viruses New York: Elsvier
5.	Ghabrial, S.A., 1980 Effects of fungal viruses on their hosts. Annual Rew. Of Phtophology

Weekly Detailed Course Contents

Week 1 - Theoretical

dsRNA genetic factors from different biological systems

Week 2 - Theoretical

dsRNA systems from yeast, fungi, plants and animals

Week 3 - Theoretical

dsRNA biology, RNA ınterference

Week 4 - Theoretical

The RNAi revolution, RNAi based methods, RNAi and cosuppression: dsRNA as an agent of sequence specific genetic silencing in animals and plants

Week 5 - Theoretical

The dsRNA activated protein kinase PKR, RNA silencing

Week 6 - Theoretical

Significance of dsRNA genetic elements in plant pathogenic fungi

Week 7 - Theoretical

Molecular biology

Week 8 - Theoretical

Effect of dsRNA mycoviruses on host phenotypes

Week 9 - Theoretical

dsRNA associated with Hypovirulent strains of Cryphonectria parasitica

Week 10 - Theoretical

Transmitted diseased state in Ophiostoma ulmi

Week 11 - Theoretical

dsRNA viruses of Gaeumannonmyces graminis var. tiritici

Week 12 - Theoretical

The viruses of Helminthosporium victorie

Week 13 - Theoretical

The viruses of Helminthosporium victorie

Week 14 - Theoretical

Enharced virulence associated with dsRNA

Assessment Methods and Criteria

Type of Assessment	Count	Percent
Midterm Examination	1	%30
Final Examination	1	%70

Workload Calculation

Activities	Count	Preparation	Time	Total Work Load (hours)
Lecture - Theory	14	2	2	56
Lecture - Practice	14	2	2	56
Midterm Examination	1	16	1	17
Final Examination	1	20	1	21
TOTAL WORKLOAD (hours)				150

Contribution of Learning Outcomes to Programme Outcomes

	PÇ-1	PÇ-2	PÇ-3	PÇ-4	PÇ-5	PÇ-6	PÇ-7
OÇ-1	3	4	5	4	5	4	4
OÇ-2	3	4	5	4	5	4	4
OÇ-3	3	4	5	4	5	4	4
OÇ-4	3	4	5	4	5	4	4
OÇ-5	3	4	5	4	5	4	4

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