Information Package / Course Catalogue
Mechanisms of Enzymatic Catalysis
Course Code: KİM650
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 3
Prt.: 0
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

The aim of this course is to understand , realize and investigate the reaction mechanisms of enyzme reactions.

Course Content

To review the basic principles of enzymology and enzymes and to investigate the enzyme catalyst mechanisms.

Name of Lecturer(s)
Learning Outcomes
1.Learns enzymes and catalysis.
2.Knows the mechanisms of enzyme catalysed reactions.
3.Learns the chemical meaning of metabolic pathways.
4.Learns the enzyme catalysed elimination, izomerization and rearrangement reactions.
5.Learns the catalytic mechanism of special enzymes in metabolism
Recommended or Required Reading
1.Enzymatic Reaction Mechanisms, C. Walsh 1979, W. H. Freeman and Company, ISBN 0-7167-0070-0
2.Enzim Kataliz Mekanizmaları basılmamış ders notları. Doç. Dr. A. Alev Karagözler.
Weekly Detailed Course Contents
Week 1 - Theoretical
Introduction: Enzymes and catalysis. Types of enzymatic catalysis.
Week 2 - Theoretical
Enzyme – catalysed group transfer reactions.
Week 3 - Theoretical
Endo- and ekzo – peptidases.
Week 4 - Theoretical
Phosphoryl transfer: Kinases
Week 5 - Theoretical
Phosphoryl transfer: Phosphatases.
Week 6 - Theoretical
Other group transfer reactions.
Week 7 - Theoretical
Enzymatic oxidation – reduction reactions.
Week 8 - Theoretical
Nicotinamide coenzymes. Flavine – dependent reactions. (Midterm Examination)
Week 9 - Theoretical
Enzyme catalysed elimination, izomerization and rearrangement reactions.
Week 10 - Theoretical
Enzymatic reactions that make and break C-C bonds.
Week 11 - Theoretical
Decarboxylation – carboxylation reactions.
Week 12 - Theoretical
The chemical logic of metabolic pathways.
Week 13 - Theoretical
Examples to the enzymatic reactions.
Week 14 - Theoretical
Examples to the enzymatic reactions.
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%30
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory144398
Midterm Examination138240
Final Examination160262
TOTAL WORKLOAD (hours)200
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
OÇ-1
5
4
3
OÇ-2
5
4
3
3
2
3
OÇ-3
5
4
3
3
3
OÇ-4
5
4
3
3
3
OÇ-5
5
4
3
3
3
Adnan Menderes University - Information Package / Course Catalogue
2026