Information Package / Course Catalogue
Molecular Mechanisms of Disease
Course Code: BYK603
Course Type: Required
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 3
Prt.: 0
Credit: 3
Lab: 0
ECTS: 5
Objectives of the Course

The aim of this course is to provide the students with the knowledge of biochemistry, microbiology, genetics, medical biology and system biology that they have acquired during their education with the mechanisms that form the basis of diseases and to link all learned metabolic pathways with diseases. In the application part of the course, it is envisaged that the current laboratory tests used in the diagnosis and follow-up of the disease and the basic principles of the analysis methods will be provided to the students in the related department of the central laboratory under the supervision of the responsible faculty member / members and to provide the students with the knowledge of the analysis process.

Course Content

Cell and extracellular matrix, cell injury, cell death, adaptation and repair. Inflammation, shock and sepsis, hemostasis and thrombosis, and metabolic diseases, identification of the molecular mechanisms involved in the pathogenesis of diseases of the immune system.

Name of Lecturer(s)
Learning Outcomes
1. To have knowledge of basic theoretical metabolism related to metabolism and to help understanding biochemistry
2.To have basic theoretical knowledge about cellular metabolism
3.To be able to critically analyze a bundle of information about cellular metabolism
4.To be able to interpret the problems related to metabolism on various models
5.To be able to present research findings related to metabolism to both academic and non-academic communities effectively
Recommended or Required Reading
1.Biology of Disease. Eds: Ahmed N., Dawson M., Smith C., Wood E. 2007 by Taylor and &Francis Group, New York.
2.Textbook of Clinical Chemistry and Molecular Diagnostics. Eds: Burtis CA, Ashwood ER, Bruns DE, 4th edition, 2006, Elsevier Saunders, St Louis.
3.Human Molecular genetics 3. Tom Strachan and Andrew P. Read. Garland Science, UK 2004
Weekly Detailed Course Contents
Week 1 - Theoretical
Introduction-Endocrine system diseases and its examination
Week 2 - Theoretical
Formation mechanisms of neoplastic diseases and examination at molecular level,Neoplastic disease markers
Week 3 - Theoretical
Molecular mechanism and diagnostic techniques of infectious diseases
Week 4 - Theoretical
Molecular mechanisms of blood diseases Hemoglobinopathies, Anemia (Fe metabolism), Thalassemia, G6PDH deficiency, Hemophilia
Week 5 - Theoretical
Molecular development mechanisms of autoimmune diseases
Week 6 - Theoretical
Formation mechanisms of cardiac circulatory system disorders Atherosclerosis (Hypercholesterolemia) Myocardial infarction and plasma enzymes, marker proteins Thromboembolism markers
Week 7 - Theoretical
Kidney structure and function Water, Na, K, Ca, Pi, Mg homeostasis disorders. Renal function tests, Electrolyte, citrate, oxalate analysis
Week 8 - Intermediate Exam
Molecular Mechanisms of Disease Midterm
Week 9 - Theoretical
Gastrointestinal system, molecular mechanism of liver diseases Liver function tests, plasma proteins Hepatitis, Cirrhosis, Cholelitiasis
Week 10 - Theoretical
Molecular mechanisms of carbohydrate metabolism diseases and laboratory analysis Diabetes Mellitus, Hypoglycemia, Ketone bodies and carbohydrate metabolism laboratory tests
Week 11 - Theoretical
Molecular mechanisms of aging and degenerative diseases
Week 12 - Theoretical
Molecular mechanism of connective tissue diseases and its molecular markers
Week 13 - Theoretical
Molecular basis of metabolic diseases, screening and determination in laboratory
Week 14 - Theoretical
Molecular basis of genetic diseases, screening and determination in laboratory
Week 15 - Theoretical
Diseases of membrane organelles and cell skeleton, Plasma membrane diseases, Mitochondrial diseases, Lysosomal diseases, muscular dystrophies
Week 16 - Final Exam
Molcular Mechanism of Disease Final Exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%40
Final Examination1%60
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory144284
Midterm Examination118220
Final Examination120121
TOTAL WORKLOAD (hours)125
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
OÇ-1
5
5
4
5
5
OÇ-2
5
5
5
4
5
OÇ-3
5
4
5
5
5
OÇ-4
5
5
4
5
4
OÇ-5
5
4
5
5
5
Adnan Menderes University - Information Package / Course Catalogue
2026