Information Package / Course Catalogue
Oxidative Stress, Free Radicals and Antioxidant Defense
Course Code: BYK608
Course Type: Required
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 2
Credit: 3
Lab: 0
ECTS: 5
Objectives of the Course

The aim of this course is to give the students the understanding of free radical types and radicalic reactions in biological systems, to give the students an understanding of oxidative damage which is one of the most emphasized subjects of science by giving basic information about free radicals

Course Content

Normal metabolic function or examination of free radicals generated under stress conditions and effects of free radicals on cell signaling and gene expression. Relationships of oxidant and antioxidant. Free radical scavengers against the destructive effects of free radicals and antioxidants, Oxidative damage in connection with pathogenesis of aging and disease.

Name of Lecturer(s)
Learning Outcomes
1.To understand the effects of oxidative damage on lipids, DNA and proteins
2.Literature review and interpretation of free radicals
3.To learn the types of free radicals
4.To be able to understand and use conventional biochemical techniques used in the determination of free radicals
5.To understand the mechanisms of action of free radicals
Recommended or Required Reading
1.Oxidative stress: oxidants and antioxidants Helmunt Sies
2.Cellular antioxidant defense mechanisms Ching Kuang Chow
3.B.Hallwell, J.M.C. Gutterdge, “Free Radicals in Biology and Medicine”, fourth edition,Oxford Science Publications, 2007
Weekly Detailed Course Contents
Week 1 - Theoretical
Free Radicals
Week 2 - Theoretical
Types of free radicals; reactive oxygen species, reactive nitrogen species
Week 3 - Theoretical
Superoxide radical, hydroxyl radical (fenton reaction), ozone
Week 4 - Theoretical
Peroxyl and alkoxyl radical, nitric oxide radical, sulfur radical
Week 5 - Theoretical
Free radical formation, endogenous effects, exogenous effects
Week 6 - Theoretical
Mechanisms of action of free radicals I
Week 7 - Theoretical
Mechanisms of action of free radicals II
Week 8 - Intermediate Exam
Oxidative Stress, Free Radicals and Antioxidant Defense Midterm Exam
Week 9 - Theoretical
Mechanisms of action of free radicals III
Week 10 - Theoretical
Effects of free radicals on proteins
Week 11 - Theoretical
Effects of free radicals on lipids
Week 12 - Theoretical
Effects of free radicals on DNA
Week 13 - Theoretical
Measurements of free radicals
Week 14 - Theoretical
Oxidative Stress
Week 15 - Theoretical
Antioxidant Defense
Week 16 - Final Exam
Oxidative Stress, Free Radicals and Antioxidant Defense Final Exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%40
Final Examination1%60
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory144284
Midterm Examination118220
Final Examination119221
TOTAL WORKLOAD (hours)125
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
OÇ-1
5
4
5
4
5
OÇ-2
5
4
5
5
4
OÇ-3
5
5
5
4
5
OÇ-4
5
4
4
5
5
OÇ-5
5
4
5
4
5
Adnan Menderes University - Information Package / Course Catalogue
2026