Information Package / Course Catalogue
Biochemistry of Neurodegenerative Disorders
Course Code: BYK624
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 0
Credit: 2
Lab: 0
ECTS: 3
Objectives of the Course

The aim of this course is to investigate the metabolic roles of neurotransmitters formed by decarboxylation of important amino acids and molecular level of neurons, to give detailed information about neuron biochemistry, to discuss the development of the nervous system and its connections with neurodegenerative diseases.

Course Content

Mechanisms and pathogenesis of degenerative diseases of central and peripheral nervous. (Parkinson's Disease (PD), Alzheimer's Disease (AD), Gaucher's disease, Amyotrophic lateral sclerosis, Multiple Sclerosis, etc.) Neuronal cell death, aggregation, and mitochondrial pathology, epidemiological studies, genetic studies, neurobiomarkers, gene therapy. Relationship between neurodegenerative diseases and environmental toxic substances and aging.

Name of Lecturer(s)
Learning Outcomes
1. Interpret the reactions of neurotransmitters
2.To be able to comprehend information about nerve cells and nerve conduction
3.Interpret neuron biochemistry and its relationship with diseases
4.Obtaining information about neurodegenerative diseases and their formation mechanisms
5.Literature review and interpretation of recent developments
Recommended or Required Reading
1.Intracellular Traffic and Neurodegenerative Disorders:Peter H. St. George-Hyslop
2.Oliver von Bohlen und Halbach and Rolf Dermietzel, Neurotransmitters and Neuromodulators, Wiley-Blackwell (2006).
3.Neurodegenerative Diseases: Unifying Principles, Jagan A Pillai
Weekly Detailed Course Contents
Week 1 - Theoretical
Overview of amino acid metabolism
Week 2 - Theoretical
Decarboxylation reactions of amino acids
Week 3 - Theoretical
Neurotransmitters
Week 4 - Theoretical
Acetylcholine and dopamine
Week 5 - Theoretical
Gamma-amino butyric acid
Week 6 - Theoretical
Glutamate and aspartate
Week 7 - Theoretical
Glycine and histamine
Week 8 - Intermediate Exam
Biochemistry of Neurodegenerative Disorders Midterm Exam
Week 9 - Theoretical
Norepinephrine and serotonin
Week 10 - Theoretical
Introduction to neurobiochemistry and structural properties of nerve cells
Week 11 - Theoretical
Neuron biochemistry: Structure and functions of neurons
Week 12 - Theoretical
Neuron-glial cells
Week 13 - Theoretical
Neuropeptides and Receptors
Week 14 - Theoretical
Ion channels and structures
Week 15 - Theoretical
Neurodegenerative diseases
Week 16 - Final Exam
Biochemistry of Neurodegenerative Disorders Final Exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%40
Final Examination1%60
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory141242
Midterm Examination114216
Final Examination115217
TOTAL WORKLOAD (hours)75
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
OÇ-1
5
4
5
4
5
OÇ-2
5
5
4
5
5
OÇ-3
5
4
5
5
4
OÇ-4
5
4
5
4
5
OÇ-5
5
4
4
5
4
Adnan Menderes University - Information Package / Course Catalogue
2026