Information Package / Course Catalogue
Biochemistry of Musculoskeletal System
Course Code: BYK631
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 3
Prt.: 0
Credit: 3
Lab: 0
ECTS: 3
Objectives of the Course

The aim of this course is to enable students to comprehend the tissue-specific biochemical reactions taking place in bone, cartilage, fat and muscle tissues and to interpret the similarities and differences between their metabolisms.

Course Content

Biochemistry of bone, cartilage, adipose and muscle tissue and related biochemical tests. Understanding the molecular mechanisms in pathogenesis of musculoskeletal system diseases.

Name of Lecturer(s)
Learning Outcomes
1.To be able to remember the basic concepts of bone, cartilage, muscle and adipose tissue metabolism
2.Be able to write biochemical reactions specific to bone, cartilage, muscle and adipose tissues
3.To be able to comprehend the differences in metabolic pathways in musculoskeletal system tissues
4.To be able to comprehend the importance of reactions taking place in organs forming organs for organ function
5.To be able to interpret the structure-function relationship in motion system tissues
Recommended or Required Reading
1.The Musculoskeletal system: embryology, biochemistry, and physiology :Richard L. Cruess
Weekly Detailed Course Contents
Week 1 - Theoretical
Definition of tissue, organ and system. Differentiation of tissues
Week 2 - Theoretical
General properties of bone tissue. Bone tissue matrix.
Week 3 - Theoretical
Importance of collagen and minerals for bone tissue.
Week 4 - Theoretical
Enzymatic reactions in osteoclast and osteoblast cells and regulation of these reactions.
Week 5 - Theoretical
Hormonal regulation of calcium levels in bone tissue and “remodeling” reactions of bone. Bone mineralization.
Week 6 - Theoretical
General features of cartilage tissue.
Week 7 - Theoretical
General properties of adipose tissue. White and brown fat texture.
Week 8 - Intermediate Exam
Biochemistry of Musculoskeletal System Midterm Exam
Week 9 - Theoretical
Enzymatic reactions in adipose tissue cells and hormonal regulation of these reactions.
Week 10 - Theoretical
Triglyceride biosynthesis and storage in adipose tissue.
Week 11 - Theoretical
Endocrine functions of adipose tissue. Leptin and its role in obesity.
Week 12 - Theoretical
Classification and general features of muscle tissue. Important proteins in muscle contraction. Biochemical mechanism of muscle contraction. Creatine phosphate metabolism.
Week 13 - Theoretical
Regulation of glycolysis and gluconeogenesis in muscle tissue.
Week 14 - Theoretical
Use of energy sources in muscle tissue in rest and exercise state. Energy metabolism in muscle tissue.
Week 15 - Theoretical
Diseases of musculoskeletal system.
Week 16 - Final Exam
Biochemistry of Musculoskeletal System Final Exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%40
Final Examination1%60
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory120118
Lecture - Practice91445
Midterm Examination1516
Final Examination1516
TOTAL WORKLOAD (hours)75
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
OÇ-1
5
4
5
4
5
OÇ-2
5
5
4
5
5
OÇ-3
5
4
5
5
4
OÇ-4
5
5
4
5
5
OÇ-5
5
4
5
4
5
Adnan Menderes University - Information Package / Course Catalogue
2026