Information Package / Course Catalogue
Cancer Cell Signaling Mechanisms
Course Code: ONK603
Course Type: Required
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 2
Credit: 3
Lab: 0
ECTS: 4
Objectives of the Course

It is aimed to explain the signal transmission mechanisms in cancer cells in detail.

Course Content

Receptor types and activation mechanisms - Signal transduction via tyrosine kinase growth factor receptor - Signal transmission in cell death - The role of PI3 Kinases in cell signal transmission

Name of Lecturer(s)
Learning Outcomes
1.Can express signal transmission in cancer molecular biology in general terms
2.Recognize and understand cancer signal transmission systems and molecular targets, molecular mechanisms of control of transcriptional regulators
3.Understand the signal mechanisms of common cancers with examples
4.Comprehend the signaling changes in cancer cell division and life
5.Can analyze and plan studies on cancer cell signaling mechanisms
Recommended or Required Reading
1.Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
2.Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3.AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4.Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
5.Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
6.Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
7.The Biology of Cancer Robert A. Weinberg, Gariand Science 2007
8.Cancer Principles and Practice of Oncology Devita VT, Lawrence TS, Rosenberg SA, Wolters Kluwer& Lippincott Willams & Wilkins 2008 Eighth Edition.
Weekly Detailed Course Contents
Week 1 - Theoretical & Practice
Cancer cell signaling pathways overview
Week 2 - Theoretical & Practice
The role of intracellular signal transduction mechanisms in cancer diagnosis and treatment
Week 3 - Theoretical & Practice
Steroid hormone and nuclear receptor signal pathways
Week 4 - Theoretical & Practice
Mitogen-Activated Protein Kinase (MAPK) signal pathway
Week 5 - Theoretical & Practice
ErbB Receptor family signal pathway in carcinogenesis and targeted therapies
Week 6 - Theoretical & Practice
Protein Kinase C signal pathway in carcinogenesis
Week 7 - Theoretical & Practice
Cancer signaling systems and molecular targets-1
Week 8 - Theoretical & Practice
Cancer signaling systems and molecular targets-2 (Midterm)
Week 9 - Theoretical & Practice
Angiogenic and anti-angiogenic signal pathways in cancer
Week 10 - Theoretical & Practice
Met signal pathway in carcinogenesis
Week 11 - Theoretical & Practice
Signal transduction and transcription factors in lung cancer
Week 12 - Theoretical & Practice
Signal transmission and transcription factors in breast cancer
Week 13 - Theoretical & Practice
PI3K / AKT / mTOR pathway in cancer
Week 14 - Theoretical & Practice
Signal transduction and transcription factors in adult and pediatric tumors
Week 15 - Final Exam
Final
Assessment Methods and Criteria
Type of AssessmentCountPercent
Assignment1%5
Quiz1%5
Midterm Examination1%20
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory140228
Lecture - Practice140228
Assignment2408
Quiz1011
Midterm Examination1426
Final Examination124226
TOTAL WORKLOAD (hours)97
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
PÇ-13
PÇ-14
PÇ-15
OÇ-1
5
5
5
5
5
5
5
4
4
5
5
5
5
5
5
OÇ-2
5
5
5
5
5
5
5
5
5
5
5
4
4
5
5
OÇ-3
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
OÇ-4
5
5
5
5
5
5
5
5
5
5
4
5
5
5
5
OÇ-5
5
5
5
4
4
4
4
5
5
5
5
4
5
5
5
Adnan Menderes University - Information Package / Course Catalogue
2026