Information Package / Course Catalogue
DNA Damage and Repair Mechanism in Cancer
Course Code: ONK617
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 2
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

Factors that affect the DNA damage and development that occur in cancer, its mechanisms, DNA repair disorders and DNA damage in the formation and treatment of cancer.

Course Content

Topics such as Free radical damage in cancer, DNA damage mechanisms in cancer development, base change repair of DNA damage, DNA damage and methods of determining repair mechanism disorders will be covered.

Name of Lecturer(s)
Learning Outcomes
1.Understands the identification of DNA damage and its types and the properties of the biological changes that occur.
2.Explain DNA repair mechanisms.
3.Knows and learns the DNA repair mechanisms and their role in cancer development.
4.Knows and learns the DNA repair mechanisms and their role in cancer treatment.
5.Examine the molecular properties of DNA damage and repair mechanism disorders and their reflection on the clinic in oncology.
Recommended or Required Reading
1.Principles and Practise of Oncology 7th edition. Vincent T De Vita 2005.
2.Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3.AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4.The Biology of Cancer Robert A. Weinberg, Gariand Science 2007
Weekly Detailed Course Contents
Week 1 - Theoretical & Practice
Introduction to DNA damage and mechanisms
Week 2 - Theoretical & Practice
Free radical damage in cancer
Week 3 - Theoretical & Practice
Radiation damage in cancer
Week 4 - Theoretical & Practice
DNA damage mechanisms in cancer development
Week 5 - Theoretical & Practice
Mismatch repair of DNA damage
Week 6 - Theoretical & Practice
Base excision repair of DNA damage
Week 7 - Theoretical & Practice
Single strand breaks in DNA
Week 8 - Theoretical & Practice
Methods of detecting DNA damage and repair mechanism disorders-1 (Midterm)
Week 9 - Theoretical & Practice
Double strand breaks in DNA
Week 10 - Theoretical & Practice
Transcriptionally active zone repair
Week 11 - Theoretical & Practice
Repair after replication
Week 12 - Theoretical & Practice
Chromosome stability
Week 13 - Theoretical & Practice
Methods of detecting DNA damage and repair mechanism disorders-2
Week 14 - Theoretical & Practice
Reflections of DNA damage and repair mechanism disorders in oncology clinic
Week 15 - Final Exam
Final
Assessment Methods and Criteria
Type of AssessmentCountPercent
Assignment1%5
Quiz1%5
Midterm Examination1%20
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory141242
Lecture - Practice141242
Assignment124125
Quiz1819
Midterm Examination124226
Final Examination148250
TOTAL WORKLOAD (hours)194
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
PÇ-13
PÇ-14
PÇ-15
OÇ-1
5
5
5
3
2
2
2
2
5
5
5
5
5
3
5
OÇ-2
5
5
5
3
2
2
2
2
5
5
5
5
5
3
5
OÇ-3
5
5
5
3
2
2
2
2
5
5
5
5
5
3
5
OÇ-4
5
5
5
3
2
2
2
2
5
5
5
5
5
3
5
OÇ-5
5
5
5
3
2
2
2
2
5
5
5
5
5
3
5
Adnan Menderes University - Information Package / Course Catalogue
2026