Information Package / Course Catalogue
Metastasis Biology
Course Code: ONK623
Course Type: Area Elective
Couse Group: Third Cycle (Doctorate Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 2
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

To give information about the concepts of invasion and metastasis in cancer molecular biology and their clinical responses.

Course Content

Molecular properties and clinical features of cancer cell difference from normal cell, changes in cell membrane in cancer, intercellular communication changes in cancer tissue, cell adhesion molecules and cancer, angiogenesis, metastasis development stages and metastasis related genes.

Name of Lecturer(s)
Learning Outcomes
1.Explain the concepts of invasion and metastasis in cancer
2.Discusses the metastasis steps in cancer
3.Examines the mechanisms and genes associated with metastasis.
4.Discusses the clinical results of metastasis.
5.Knows EMT process in cancer
Recommended or Required Reading
1.A beginner’s guide to targeted cancer treatments / by Elaine Vickers. (Elaine Ruth), author. Hoboken, NJ : Wiley, 2018. LCCN 2018000469 (print) | LCCN 2018000728 (ebook) |ISBN 9781119126836 (pdf) | ISBN 9781119126829 (epub) | ISBN 9781119126799 (pbk.) LCC RC271.C5 (ebook) | LCC RC271.C5 (print) | NLM QZ 267 |DDC 616.99/4061–dc23 LC record available at https://lccn.loc.gov/2018000469
2.. A practical guide to cancer systems biology / Hsueh-Fen Juan, Hsuan-Cheng Huang, authors. New Jersey : World Scientific, [2017] LCCN 2017026929 | ISBN 9789813229143 LCC RC267 .J83 2017 | DDC 616.99/40072--dc23. LC record available at https://lccn.loc.gov/2017026929. World Scientific Publishing Co. Pte. Ltd.
Weekly Detailed Course Contents
Week 1 - Theoretical & Practice
Cancer cell difference from normal cell
Week 2 - Theoretical & Practice
Cancer from molecule to cell, from cell to tissue
Week 3 - Theoretical & Practice
Cell membrane changes in cancer
Week 4 - Theoretical & Practice
Communication changes between cells in cancer tissue
Week 5 - Theoretical & Practice
Substance, protein transport and exhaust in cancer
Week 6 - Theoretical & Practice
Cell polarity in cancer
Week 7 - Theoretical & Practice
Cell adhesion molecules and cancer
Week 8 - Theoretical & Practice
Signal transduction pathways and cancer relationship in embryogenesis and cell differentiation-1 (Midterm)
Week 9 - Theoretical & Practice
Signal transduction pathways and cancer relationship in embryogenesis and cell differentiation-2
Week 10 - Theoretical & Practice
Angiogenesis and lymphangiogenesis
Week 11 - Theoretical & Practice
Epithelial mesenchymal transition-I
Week 12 - Theoretical & Practice
Epithelial mesenchymal transition-II
Week 13 - Theoretical & Practice
Micrometastasis and treatment resistance
Week 14 - Theoretical & Practice
Dormant cell concept
Week 15 - Final Exam
Final
Assessment Methods and Criteria
Type of AssessmentCountPercent
Assignment1%5
Quiz1%5
Midterm Examination1%20
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory141242
Lecture - Practice141242
Assignment124125
Quiz1819
Midterm Examination124226
Final Examination148250
TOTAL WORKLOAD (hours)194
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
PÇ-13
PÇ-14
PÇ-15
OÇ-1
5
5
5
2
2
2
2
2
5
5
5
5
5
2
5
OÇ-2
5
5
5
2
2
2
2
2
5
5
5
5
5
2
5
OÇ-3
5
5
5
2
2
2
2
2
5
5
5
5
5
2
5
OÇ-4
5
5
5
2
2
2
2
2
5
5
5
5
5
2
5
OÇ-5
5
5
5
2
2
2
2
2
5
5
5
5
5
2
5
Adnan Menderes University - Information Package / Course Catalogue
2026