Information Package / Course Catalogue
Basic Mutagenicity Tests
Course Code: BİO531
Course Type: Area Elective
Couse Group: Second Cycle (Master's Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 2
Credit: 3
Lab: 0
ECTS: 8
Objectives of the Course

The purpose of this course, the basic mutagenicity and genotoxicity studies cytogenetic tests provide basic information about the purpose and application.

Course Content

the basic mutagenicity and genotoxicity studies cytogenetic tests provide basic information about the purpose and application.

Name of Lecturer(s)
Assoc. Prof. Tülay ÇELİK
Learning Outcomes
1.To be able to learn basic information about the mutation, mutagen, mutagenicity
2.To be able to understand the importance of mutation for life
3.To be able to learn mutagenicity test systems in prokaryotes
4.To be able to learn the mutagenicity test systems in plants
5.To be able to learn mutagenicity test systems in eukaryotes
Recommended or Required Reading
1.D, Adler., J.cole et.al, Guide to short term tests for detecting mutagenic and carcinogenic chemicals, The International Commission for protection aganist environmental mutagens and carcinogens ( ICPEMC) notları
2.S.Aulard et, al., (1994), Techniques in Animal Cytogenetics, Springer Press
3.W,Wang, J.W.Gorsuch, J.S. Hughes, (1997)Plants for environmental Studies, Lewis Publishers
Weekly Detailed Course Contents
Week 1 - Theoretical
Basic information about mutation, mutagen and mutagenicity
Week 1 - Laboratory
The tool used in the experiment, Equipment Identification
Week 2 - Theoretical
Introduction to Basic mutagenicity testing, classification of tests
Week 2 - Laboratory
Preparation of Test Environments
Week 3 - Theoretical
Bacterial mutation assay (Ames test)
Week 3 - Laboratory
Ames Test aplications
Week 4 - Theoretical
use of Drosophila in Genotoxicology
Week 4 - Laboratory
Drosophila test application
Week 5 - Theoretical
Chromosome mutation tests in somatic cells
Week 5 - Laboratory
Production of somatic chromosome
Week 6 - Theoretical
micronucleus tests
Week 7 - Theoretical
Plant test systems
Week 7 - Laboratory
Introduction to Plants Used in Testing System
Week 8 - Intermediate Exam
Vicia faba micronucleus test (Middterm exam)
Week 9 - Theoretical
Allium test, Tradescantia stamen hair test
Week 9 - Laboratory
Plant Test Applications
Week 10 - Theoretical
In vitro mammalian cell cultures
Week 10 - Laboratory
Analysis of Mammalian Cells: Fundamentals of making techniques
Week 11 - Theoretical
Sister chromatid exchange
Week 11 - Laboratory
Sister Chromatid Exchange Applications
Week 12 - Theoretical
Determination of mutations in mice and other mammals
Week 12 - Laboratory
Mouse Lymphocytes Mutation Detection Trials
Week 13 - Theoretical
Chromosome staining and banding techniques
Week 13 - Laboratory
Painting and chromosome banding techniques, applications,
Week 14 - Theoretical
Comet assay
Week 14 - Laboratory
Comet assay applications
Week 15 - Final Exam
Final exam
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%30
Final Examination1%70
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory145298
Lecture - Practice144284
Assignment54020
TOTAL WORKLOAD (hours)202
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
OÇ-1
4
3
4
4
OÇ-2
4
3
4
OÇ-3
4
4
3
4
OÇ-4
4
4
3
4
OÇ-5
4
4
3
4
Adnan Menderes University - Information Package / Course Catalogue
2026