Information Package / Course Catalogue
Eukaryotic Cell Biology
Course Code: BİO565
Course Type: Area Elective
Couse Group: Second Cycle (Master's Degree)
Education Language: Turkish
Work Placement: N/A
Theory: 2
Prt.: 2
Credit: 3
Lab: 0
ECTS: 6
Objectives of the Course

Introduce to cell surface and included structures with their related functions from each to other. Explain how the molecular mechanisms realize inside the cell according to this information and discuss cell, tissue, cancer and immunity topics based on this knowledge.

Course Content

Advanced knowledge on organisation, communication and basic genetic regulation mechanisms. Introducing to how to use this knowledge in related research areas such as cancer, genetic and metabolic diseases. Explain and observe how extracellular and intracellular signal transduction mechanisms activate or repress the expression of cellular genes, anabolic and katabolic pathways.

Name of Lecturer(s)
Learning Outcomes
1.To be able to explain how extracellular and intracellular signal transduction mechanisms activate or repress the expression of cellular genes, anabolic and katabolic pathways
2.To be able to use the knowledge in solving topical scientific problems in related research areas such as cancer, genetic and metabolic diseases
3.To be able to analyze articles related with molecular cell biology and cancer
4.To be able to establish a connection between cell, tissue, cancer and immune system
5.
Recommended or Required Reading
1.Cell and Molecular Biology by Gerald Karp. 2007. John Wiley Inc.
2.Molecular Biology of the Cell. Alberts, B. et al. 5th ed. 2008. Garland Science.
3.Molecular Cell Biology. Lodish, H. et al. 5th ed. 2004. W.H. Freeman and Company.
Weekly Detailed Course Contents
Week 1 - Theoretical
Cell and Genome; Cell chemistry and biosynthesis; Proteins
Week 1 - Practice
Microscopic cell analyses
Week 2 - Theoretical
Basic genetic mechanisms: Chromosomes, DNA replication, repair and recombination.
Week 2 - Practice
Microscopic heritable material analyses
Week 3 - Theoretical
Expression of genome in cells. Control of gene expression
Week 3 - Practice
Presentation of necessary components for cell proliferation
Week 4 - Theoretical
Basic methods used in cell biology: cell separation and proliferation in culture
Week 4 - Practice
Preparing the medium used in cell proliferation.
Week 5 - Theoretical
Basic methods used in cell biology: DNA isolation, cloning and sequencing, investigation of protein structure and function, investigation of gene expression and function, cell imaging, microscopy, imaging molecules in viable cell.
Week 5 - Practice
Cell proliferation in cell culture
Week 6 - Theoretical
Intracellular organization, structure of cell membrane, lipid bilayer and membrane proteins.
Week 6 - Practice
Cell proliferation in cell culture
Week 7 - Theoretical
Transporting of small molecules via cell membrane and electrical properties of cell membrane
Week 7 - Practice
Investigation on proliferating cells and cell counting
Week 8 - Intermediate Exam
Midterm Exam
Week 9 - Practice
Determination of viable cells in culture
Week 10 - Theoretical
Cellular communication: general principles of cellular communication and cellular signal transduction, signal transduction via G-protein related cell surface receptors. Cellular signal transduction via enzyme related cell surface reseptors; signalling pathways related to protein degradation, Signal transduction in plants.
Week 10 - Practice
DNA isolation and imaging, RNA isolation, Protein isolation and western blotting
Week 11 - Theoretical
Cell cycle and control, programmed cell dead
Week 11 - Practice
Determination of the expression rate from intracellular targeted proteins
Week 12 - Theoretical
Mechanics in cell division
Week 12 - Practice
Analyse of the cells in culture for G1, S, G2, cell division
Week 13 - Theoretical
Survive and death of cells in tissues
Week 13 - Practice
Applying toxic agent to cells, calculating the concentrations
Week 14 - Theoretical
Cancer and immune system
Week 14 - Practice
Cell counting, determination of apoptosis and necrosis ratio
Assessment Methods and Criteria
Type of AssessmentCountPercent
Midterm Examination1%40
Final Examination1%60
Workload Calculation
ActivitiesCountPreparationTimeTotal Work Load (hours)
Lecture - Theory151245
Lecture - Practice152260
Term Project110010
Project110212
Midterm Examination110111
Final Examination115116
TOTAL WORKLOAD (hours)154
Contribution of Learning Outcomes to Programme Outcomes
PÇ-1
PÇ-2
PÇ-3
PÇ-4
PÇ-5
PÇ-6
PÇ-7
PÇ-8
PÇ-9
PÇ-10
PÇ-11
PÇ-12
OÇ-1
5
4
4
4
4
4
4
4
4
4
OÇ-2
5
4
4
4
4
4
4
4
4
4
OÇ-3
5
4
4
4
4
4
4
4
4
4
OÇ-4
5
4
4
4
4
4
4
4
4
4
OÇ-5
2
Adnan Menderes University - Information Package / Course Catalogue
2026